Abstract | BACKGROUND: METHODS: RESULTS: The specific loading of CAE was 0.0091 g/g of dry gel. The percentage of CAE released at 24 h at pH 3.0, 5.0 and 7.4 was approximately 63.9%, 55.0% and 44.4%, respectively. This pH-dependent release is possibly due to the degree of gel swelling, which decreased with increasing pH. The specific loading of HCA was 0.0050 g/g dry gel, and the percentage release of HCA at 24 h was around 20% at all three pH points. It is likely that HCA release is independent of pH. HCA is a hydrophobic compound, and therefore the release of HCA is affected by the partitioning of HCA between the β-CD cavity and the bulk water phase, but not by the degree of swelling of the hydrogel. The pressure sores treated with the hydrogel healed in 6 days, compared with 10 days for controls. CONCLUSIONS:
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Authors | M S Lee, S R Seo, J-C Kim |
Journal | Clinical and experimental dermatology
(Clin Exp Dermatol)
Vol. 37
Issue 7
Pg. 762-71
(Oct 2012)
ISSN: 1365-2230 [Electronic] England |
PMID | 22439751
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © The Author(s). CED © 2012 British Association of Dermatologists. |
Chemical References |
- Centella asiatica extract
- Hydrogels
- Plant Extracts
- Silk
- Triterpenes
- beta-Cyclodextrins
- hydrocortisone acetate
- Polyethyleneimine
- Fibroins
- Hydrocortisone
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Topics |
- Animals
- Centella
- Fibroins
(therapeutic use)
- Hydrocortisone
(analogs & derivatives, therapeutic use)
- Hydrogels
(chemical synthesis, therapeutic use)
- Male
- Mice
- Mice, Inbred ICR
- Plant Extracts
- Polyethyleneimine
(therapeutic use)
- Pressure Ulcer
(drug therapy)
- Silk
- Skin
(drug effects)
- Triterpenes
(therapeutic use)
- Wound Healing
(drug effects)
- beta-Cyclodextrins
(therapeutic use)
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