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Hypothalamic pituitary complications in Kabuki syndrome.

Abstract
Kabuki syndrome is characterized by distinctive facial features, multiple anomalies and mental retardation. In this syndrome, structural CNS abnormalities are commonly observed, but congenital abnormalities in the pituitary gland or hypothalamus have rarely been reported. We searched the published medical literature on the complications in hypothalamic pituitary axis in this syndrome. As a result, only nine patients with Kabuki syndrome had been reported to have complications in hypothalamic pituitary axis in previous papers. Among the nine reported patients and one presented case in this report, GH deficiency was the most frequent complication and found in six patients. Precocious puberty and central diabetes insipidus (DI) was identified in two cases, respectively, and ACTH deficiency was found in one. One case had combination of GH deficiency and central DI. Three of the 10 patients demonstrated abnormal pituitary findings in MRI study. Two of the six patients with GH deficiency were accompanied with premature thelarche. This review highlights that patients with Kabuki syndrome could present various clinical manifestations due to abnormalities in hypothalamic pituitary axis.
AuthorsNaoko Ito, Kenji Ihara, Yasushi Tsutsumi, Noriko Miyake, Naomichi Matsumoto, Toshiro Hara
JournalPituitary (Pituitary) Vol. 16 Issue 2 Pg. 133-8 (Jun 2013) ISSN: 1573-7403 [Electronic] United States
PMID22434255 (Publication Type: Journal Article)
Chemical References
  • DNA-Binding Proteins
  • KMT2D protein, human
  • Neoplasm Proteins
Topics
  • Abnormalities, Multiple (genetics, metabolism)
  • Child
  • Child, Preschool
  • DNA-Binding Proteins (genetics)
  • Diabetes Insipidus, Neurogenic (genetics, pathology)
  • Face (abnormalities)
  • Female
  • Hematologic Diseases (complications, genetics, metabolism)
  • Humans
  • Hypothalamo-Hypophyseal System (metabolism, pathology)
  • Infant
  • Male
  • Neoplasm Proteins (genetics)
  • Vestibular Diseases (complications, genetics, metabolism)

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