Abstract | BACKGROUND AND AIMS: METHODS: We conducted a retrospective study to evaluate the potential impact of pretransplant titers on post-transplant outcomes for patients with AIH. Sixty-three patients with AIH who underwent 72 liver transplants between 1 January 1989 and 1 January 2009 were included, with a median follow up of 10 months. Patients were divided into group A (ANA or SMA ≥ 1:160) and group B (titers ≤ 1:160). RESULTS: There was no significant difference in the recurrence rates or death between patients in groups A and B, respectively. Only race appeared to impact outcomes, with African American patients having a higher incidence of death and recurrent disease post-transplant compared to other ethnicities. CONCLUSIONS: Based on our findings, pretransplant ANA and SMA levels do not appear to impact recurrence rates or outcomes following liver transplantation for AIH.
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Authors | Nader Dbouk, Samir Parekh |
Journal | Journal of gastroenterology and hepatology
(J Gastroenterol Hepatol)
Vol. 28
Issue 3
Pg. 537-42
(Mar 2013)
ISSN: 1440-1746 [Electronic] Australia |
PMID | 22432792
(Publication Type: Evaluation Study, Journal Article, Research Support, N.I.H., Extramural)
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Copyright | © 2012 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd. |
Chemical References |
- Antibodies, Antinuclear
- Autoantibodies
- Biomarkers
- anti-liver kidney microsome antibody
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Topics |
- Adult
- Black or African American
- Antibodies, Antinuclear
(blood)
- Autoantibodies
(blood)
- Biomarkers
(blood)
- Female
- Fluorescent Antibody Technique, Indirect
- Follow-Up Studies
- Graft Survival
(immunology)
- Hepatitis, Autoimmune
(ethnology, immunology, mortality, surgery)
- Humans
- Liver Transplantation
(immunology)
- Logistic Models
- Male
- Middle Aged
- Preoperative Period
- Recurrence
- Retrospective Studies
- Survival Analysis
- Treatment Outcome
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