Decreased expression of MDR1 in PEG-conjugated hemoglobin solution combined cisplatin treatment in a tumor xenograft model.

Abstract	This study aims to examine the contribution of PEG-conjugated hemoglobin combined with cisplatin to the expression of HIF-1α and MDR1 in a tumor xenograft model. Cervical carcinoma models were assigned to 4 groups and treated respectively: group 1(control); group 2, cisplatin; group 3, PEG-Hb; group 4 cisplatin plus PEG-Hb. 4 weeks later, tumor volume and MVD was significantly decreased in group 4 compared with other groups. Lower expression of HIF-1α and MDR1 were detected in group4. Taken together, our data indicated that PEG-Hb plus cisplatin can promote tumor tissue oxygenation and enhance the chemotherapy sensitivity. HIF-1α regulated MDR1 pathway correlated with this process.
Authors	Jianqun Han, Minhua Yu, Min Dai, Hongwei Li, Ruijuan Xiu, Qian Liu
Journal	Artificial cells, blood substitutes, and immobilization biotechnology (Artif Cells Blood Substit Immobil Biotechnol) Vol. 40 Issue 4 Pg. 239-44 (Aug 2012) ISSN: 1532-4184 [Electronic] England
PMID	22432540 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	ATP Binding Cassette Transporter, Subfamily B, Member 1 Antineoplastic Agents Blood Substitutes Hemoglobins Hif1a protein, mouse Hypoxia-Inducible Factor 1, alpha Subunit PEG-hemoglobin Platelet Endothelial Cell Adhesion Molecule-1 Solutions Polyethylene Glycols Cisplatin
Topics	ATP Binding Cassette Transporter, Subfamily B, Member 1 (metabolism) Animals Antineoplastic Agents (pharmacology) Blood Substitutes (chemistry, pharmacology, therapeutic use) Cisplatin (pharmacology, therapeutic use) Drug Interactions Female Gene Expression Regulation, Neoplastic (drug effects) HeLa Cells Hemoglobins (chemistry, pharmacology, therapeutic use) Humans Hypoxia-Inducible Factor 1, alpha Subunit (metabolism) Mice Platelet Endothelial Cell Adhesion Molecule-1 (metabolism) Polyethylene Glycols (chemistry, pharmacology, therapeutic use) Solutions Treatment Outcome Uterine Cervical Neoplasms (metabolism, pathology) Xenograft Model Antitumor Assays

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