Abstract | OBJECTIVE: DESIGN: Randomized, controlled, prospective study. SETTING: University hospital laboratory. SUBJECTS: Nonobstetric (not pregnant nor postpartum) and obstetrical (within 2 hrs postpartum) rabbits. INTERVENTIONS: Nonobstetric and obstetric female New Zealand white rabbits underwent fixed-pressure or fixed-volume hemorrhagic shock for 30 mins and then were rapidly resuscitated with the shed blood and Ringer's solution. Finally, they were either monitored for survival time or euthanized by exsanguination for lung tissue examination 24 hrs after hemorrhage. MEASUREMENTS AND MAIN RESULTS: CONCLUSIONS: After hemorrhage and resuscitation, obstetric rabbits had significantly shorter survival time and more severe lung injury than nonobstetric rabbits. The mechanism may be through upregulation of the signal transductions of the nuclear factor-κB pathways.
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Authors | Chao Sheng, Yan-Hong Yu, Ke-Seng Zhao, Li-Ping Huang, Robert F Lodato, Zhi-Jian Wang, Chen-Hong Wang, Sui-Hai Wang, Ding-Sheng Zha |
Journal | Critical care medicine
(Crit Care Med)
Vol. 40
Issue 5
Pg. 1570-7
(May 2012)
ISSN: 1530-0293 [Electronic] United States |
PMID | 22430240
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- NF-kappa B
- Tumor Necrosis Factor-alpha
- Intercellular Adhesion Molecule-1
- Interleukin-10
- Peroxidase
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Topics |
- Acute Lung Injury
(etiology, pathology, physiopathology)
- Animals
- Disease Models, Animal
- Female
- Intercellular Adhesion Molecule-1
(metabolism)
- Interleukin-10
(blood)
- Lung
(pathology)
- NF-kappa B
(blood)
- Peroxidase
(metabolism)
- Pneumonia
(etiology, pathology, physiopathology)
- Postpartum Period
(physiology)
- Pregnancy
- Rabbits
- Shock, Hemorrhagic
(complications, physiopathology)
- Tumor Necrosis Factor-alpha
(blood)
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