Abstract | OBJECTIVE: MATERIALS AND METHODS: RESULTS: All rats demonstrated enlargement in the bile duct, obstructive jaundice, and histopathologic ductal proliferation. MDA and SOD levels were significantly lower in the ketamine group compared with the thiopental and fentanyl groups. CAT was significantly increased in the ketamine group compared with the other groups. The best portal polymorphonuclear leukocyte and necrosis scores were in the ketamine group, but this difference was not statistically significant ( p=0.07). CONCLUSION:
Ketamine and propofol were observed to cause the least amount of oxidative stress in this rat model of induced oxidative stress generated by ligation of the common bile duct. This experiment is the first study on this subject in the literature (Tab. 3, Ref. 65).
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Authors | H Yildiz, I Coskuner, E Bulbuloglu, E Silay, E B Kurutas, Z Dogan, B Kantarceken, H Oksuz, N Senoglu, M F Yuzbasioglu, A Cetinkaya, H Ciralik |
Journal | Bratislavske lekarske listy
(Bratisl Lek Listy)
Vol. 113
Issue 3
Pg. 139-44
( 2012)
ISSN: 0006-9248 [Print] Slovakia |
PMID | 22428761
(Publication Type: Journal Article)
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Chemical References |
- Anesthetics, Dissociative
- Anesthetics, Intravenous
- Malondialdehyde
- Ketamine
- Catalase
- Superoxide Dismutase
- Propofol
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Topics |
- Anesthetics, Dissociative
(pharmacology)
- Anesthetics, Intravenous
(pharmacology)
- Animals
- Catalase
(metabolism)
- Jaundice, Obstructive
(metabolism, pathology)
- Ketamine
(pharmacology)
- Liver
(metabolism, pathology)
- Male
- Malondialdehyde
(metabolism)
- Oxidative Stress
(drug effects)
- Propofol
(pharmacology)
- Rats
- Rats, Wistar
- Superoxide Dismutase
(metabolism)
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