HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Glutathione transferase polymorphisms and risk of endometriosis associated with polychlorinated biphenyls exposure in Italian women: a gene-environment interaction.

AbstractOBJECTIVE:
To investigate the occurrence of a gene-environment interaction between glutathione transferase (GST) gene polymorphisms (GSTM1, GSTT1, GSTP1, and GSTA1) and serum polychlorinated biphenyls (PCBs) levels. This is suggested as possible risk factors for endometriosis, a multifactorial gynecological disease.
DESIGN:
Case-control study conducted from 2002 to 2005.
SETTING:
Policlinico Umberto I, "Sapienza" University of Rome and Italian National Institute for Health, Rome.
PATIENT(S):
Italian women (N = 343), with laparoscopic diagnosis and histologic confirmation of the presence (cases, N = 181) or the absence (controls, N = 162) of endometriosis.
INTERVENTION(S):
Genomic DNA extraction, multiplex polymerase chain reaction (PCR), and restriction fragment length polymorphism analysis. Determination of serum concentrations of selected PCBs by ion-trap mass spectrometry (subgroup, 63 cases and 63 controls).
MAIN OUTCOME MEASURE(S):
Endometriosis diagnosis by laparoscopy, GST genotypes, serum PCB levels.
RESULT(S):
The genotype distributions of GSTM1, GSTA1, and GSTP1 did not show any statistically significant difference between cases and controls. The GSTT1 null genotype was negatively associated with the disease. The GSTP1 wild-type genotype in the presence of medium-high blood levels of PCB153, total PCBs, or of high levels of PCB180 significantly increased the risk of endometriosis, suggesting a multiplicative interaction.
CONCLUSION(S):
The GSTs polymorphisms per se do not increase the risk of developing endometriosis. However, a gene-environment interaction was observed for GSTP1(Ile/Ile) and GSTM1 null genotypes, modulating the effect of PCB153, PCB180, and of total PCBs on disease risk.
AuthorsSusanna Vichi, Emanuela Medda, Anna Maria Ingelido, Annamaria Ferro, Serena Resta, Maria Grazia Porpora, Annalisa Abballe, Lorenza Nisticò, Elena De Felip, Simonetta Gemma, Emanuela Testai
JournalFertility and sterility (Fertil Steril) Vol. 97 Issue 5 Pg. 1143-51.e1-3 (May 2012) ISSN: 1556-5653 [Electronic] United States
PMID22424617 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Environmental Pollutants
  • Polychlorinated Biphenyls
  • glutathione S-transferase T1
  • GSTA1 protein, human
  • GSTP1 protein, human
  • Glutathione S-Transferase pi
  • Glutathione Transferase
  • glutathione S-transferase M1
Topics
  • Adult
  • Case-Control Studies
  • Chi-Square Distribution
  • Endometriosis (chemically induced, enzymology, etiology, genetics, pathology)
  • Environmental Pollutants (adverse effects, blood)
  • Female
  • Gene Frequency
  • Gene-Environment Interaction
  • Genetic Predisposition to Disease
  • Glutathione S-Transferase pi (genetics)
  • Glutathione Transferase (genetics)
  • Humans
  • Italy
  • Laparoscopy
  • Logistic Models
  • Mass Spectrometry
  • Odds Ratio
  • Polychlorinated Biphenyls (adverse effects, blood)
  • Polymerase Chain Reaction
  • Risk Assessment
  • Risk Factors
  • Time Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: