Extracorporeal photopheresis as a curative treatment strategy in non epidermotropic T-cell lymphoma and large granular lymphocyte leukemia.

Abstract

BACKGROUND:

To evaluate the efficacy of extracorporeal photopheresis (ECP) in noncutaneous T-cell lymphoma and large granular lymphocytes leukemia (LGL).

PATIENTS AND METHODS:

We have treated 12 refractory/relapsed patients. Six peripheral T-cell lymphoma (PTCL), one T-lymphoblastic lymphoma and five LGL with blood involvement received six biweekly leukapheresis as induction phase, followed by one course a week for 4 weeks as consolidation and one course of maintenance per month for responders until progression/relapse or disappearance of the peripheral clone.

RESULTS:

Six patients responded to phototherapy. Two PTCL and two LGL achieved a complete response (CR) and two other PTCL a partial response. The median duration of CR was 117 months (45-150 months) for these four patients. The peripheral clone followed by flow cytometry decreased in all six responders. Two patients with a complete disappearance of the peripheral clone have not relapsed.

CONCLUSIONS:

As for cutaneous T-cell lymphoma, ECP therefore to be efficient for PTCL and LGL. Early decrease and disappearance of the peripheral clone were the indicators of clinical response and nonrelapse, respectively.

• Authors: F Garban, S Carras, P Drillat, M C Jacob, B Fabre, M Callanan, S Courby, C Makowski, J Y Cahn, R Gressin
• Journal: Annals of oncology : official journal of the European Society for Medical Oncology (Ann Oncol) Vol. 23 Issue 9 Pg. 2386-2390 (Sep 2012) ISSN: 1569-8041 [Electronic] England
• PMID: 22422944 (Publication Type: Journal Article)

Topics

• Adult
• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Female
• Humans
• Leukemia, Large Granular Lymphocytic (drug therapy)
• Lymphoma, T-Cell (drug therapy)
• Male
• Middle Aged
• Photopheresis
• Treatment Outcome