Abstract |
A 45-year-old man, on carbamazepine for the past 3 months, was referred as a case of atypical measles. On examination, he had high-grade fever, generalized itchy rash, cough, vomiting and jaundice. A provisional diagnosis of drug hypersensitivity syndrome to carbamazepine was made with a differential diagnosis of viral exanthema with systemic complications. Laboratory investigations revealed leukocytosis with eosnophilia and elevated liver enzymes. Real-time multiplex polymerase chain reaction (PCR) on throat swab and blood was suggestive of human herpesvirus-6 (HHV-6). Measles was ruled out by PCR and serology. The diagnosis of drug-induced hypersensitivity syndrome (DIHS) was confirmed, which could explain all the features manifested by the patient. HHV-6 infects almost all humans by age 2 years. It infects and replicates in CD4 T lymphocytes and establishes latency in human peripheral blood monocytes or macrophages and early bone marrow progenitors. In DIHS, allergic reaction to the causative drug stimulates T cells, which leads to reactivation of the herpesvirus genome. DIHS is treated by withdrawal of the culprit drug and administration of systemic steroids. Our patient responded well to steroids and HHV-6 was negative on repeat real-time multiplex PCR at the end of treatment.
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Authors | Najeeba Riyaz, S Sarita, G Arunkumar, S Sabeena, Neeraj Manikoth, C P Sivakumar |
Journal | Indian journal of dermatology, venereology and leprology
(Indian J Dermatol Venereol Leprol)
2012 Mar-Apr
Vol. 78
Issue 2
Pg. 175-7
ISSN: 0973-3922 [Electronic] United States |
PMID | 22421649
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticonvulsants
- Carbamazepine
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Topics |
- Anticonvulsants
(adverse effects)
- Carbamazepine
(adverse effects)
- Drug Eruptions
(etiology, virology)
- Herpesvirus 6, Human
- Humans
- Male
- Middle Aged
- Roseolovirus Infections
(virology)
- Virus Activation
(drug effects)
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