Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung.

Abstract

In contrast to leukocytosis, paraneoplastic hypereosinophilia is uncommon in lung cancer. We present a patient with large-cell carcinoma of the lung, in which cancer cells generate large amounts of GM-CSF leading to a leukemoid reaction with prominent hypereosinophilia and potentially involved in autocrine tumor stimulation.

• Authors: Verena Lammel, Christina Stoeckle, Barbara Padberg, Roland Zweifel, Dirk L Kienle, Walter H Reinhart, Hans-Uwe Simon
• Journal: Lung cancer (Amsterdam, Netherlands) (Lung Cancer) Vol. 76 Issue 3 Pg. 493-5 (Jun 2012) ISSN: 1872-8332 [Electronic] Ireland
• PMID: 22420949 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Granulocyte Colony-Stimulating Factor

Topics

• Carcinoma, Large Cell (complications, drug therapy, metabolism)
• Eosinophilia (diagnosis, etiology)
• Fatal Outcome
• Granulocyte Colony-Stimulating Factor (blood)
• Humans
• Lung Neoplasms (complications, drug therapy, metabolism)
• Male
• Middle Aged