Abstract | BACKGROUND: Cytogenetic abnormalities have been detected in 40-60% of patients with de novo myelodysplastic syndrome (MDS). Some reports suggest that Asian and Western MDS patients have different cytogenetic features. PATIENTS AND METHODS: We retrospectively analyzed 168 patients with de novo MDS and compared our results with other Chinese centers to investigate the prevalence and cytogenetic characteristics of MDS in China. RESULTS: In our study, chromosome abnormalities were detected in 40.48% of patients (68/168). Although the median survival time did not differ between younger and older (≥60 years) patients (p = 0.969), survival curves based on International Prognostic Scoring System (IPSS) cytogenetic groups and WHO Classification-Based Prognostic Scoring System (WPSS) risk groups were significantly different (p < 0.001). Survival differences were observed between patients in the normal karyotype group, sole trisomy 8 group, and poor cytogenetic group according to IPSS (p < 0.001). In agreement with the results from 2 other large Chinese centers, trisomy 8 was the most detected cytogenetic abnormality, with a prevalence of 14.21%. CONCLUSION: Trisomy 8, categorized as intermediate cytogenetic risk group in our study, is the most frequent cytogenetic abnormality in de novo MDS in China.
|
Authors | Yi Xiao, Jia Wei, Yan Chen, Kejian Zhang, Jianfeng Zhou, Yicheng Zhang |
Journal | Onkologie
(Onkologie)
Vol. 35
Issue 3
Pg. 100-6
( 2012)
ISSN: 1423-0240 [Electronic] Switzerland |
PMID | 22414973
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2012 S. Karger AG, Basel. |
Topics |
- Age Factors
- Aged
- Asian People
(genetics)
- Chromosome Aberrations
- Chromosomes, Human, Pair 8
(genetics)
- Cross-Cultural Comparison
- Cross-Sectional Studies
- Female
- Humans
- Male
- Middle Aged
- Myelodysplastic Syndromes
(genetics, mortality)
- Retrospective Studies
- Survival Analysis
- Survival Rate
- Trisomy
(genetics)
|