Effect of polymerized human placenta hemoglobin on hemodynamic parameter and cardiac function in a rat hemorrhagic shock model.

Abstract

To investigate whether polymerized human placenta hemoglobin (PolyPHb) improved hemodynamic parameter recovery and cardiac function after hemorrhagic shock, a mean arterial pressure (MAP) of 30 mmHg was maintained for 60min. Then, all the rats were randomly resuscitated with hetastarch (HES), shed blood (Whole Blood), or PolyPHb (PolyPHb). The MAP was greatly improved by PolyPHb, but it was still lower than that of the Whole Blood group. Meanwhile, the cardiac function and enzyme releases in the PolyPHb group were similar to the HES group. Therefore, our findings suggest that PolyPHb moderately improved hemodynamic recovery and provided little cardioprotective effect in hemorrhagic shock.

• Authors: Tao Li, Yongxian Jiang, Zhenyu Zhang, Sisi Zhang, Wei Wu, Daqin Liao, Yanfang Chen, Chengmin Yang, Xuewen Xu, Jin Liu
• Journal: Artificial cells, blood substitutes, and immobilization biotechnology (Artif Cells Blood Substit Immobil Biotechnol) Vol. 40 Issue 4 Pg. 256-60 (Aug 2012) ISSN: 1532-4184 [Electronic] England
• PMID: 22413828 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biopolymers
• Blood Substitutes
• Hemoglobins
• hemoglobin polymer

Topics

• Animals
• Biopolymers (pharmacology)
• Blood Pressure (drug effects)
• Blood Substitutes (pharmacology)
• Disease Models, Animal
• Female
• Heart (drug effects, physiopathology)
• Hemodynamics (drug effects)
• Hemoglobins (pharmacology)
• Humans
• Male
• Perfusion
• Placenta (chemistry)
• Pregnancy
• Rats
• Rats, Sprague-Dawley
• Recovery of Function (drug effects)
• Shock, Hemorrhagic (physiopathology)