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Revisiting the histopathologic spectrum of congenital pulmonary developmental disorders.

Abstract
A retrospective analysis of lobectomy, pneumonectomy, cystectomy specimens (10 years) and stillbirth/neonatal autopsies (5 years) was carried out to analyze the histologic spectrum of congenital pulmonary developmental disorders/malformations. The autopsy data was analyzed to identify the lesions that are more diffuse and not amenable to surgical management. A total of 166 cases of pulmonary developmental disorders/ malformation were found. Out of 2,155 stillbirth/neonatal autopsies, there were 105 cases of pulmonary hypoplasia, 2 cases of congenital pulmonary lymphangiectasis, 2 cases of extralobar sequestration, and 3 cases of congenital pulmonary airway malformation (CPAM). Among the surgical specimens, there were 21 cases of CPAM, 11 cases of intralobar sequestration, 5 cases of congenital lobar emphysema and 17 cases of bronchogenic cyst. All these malformations have been described in reference to the latest updated classification of developmental disorders/malformations.
AuthorsKirti Gupta, Ashim Das, Prema Menon, Nandita Kakkar, K L N Rao, Kusum Joshi
JournalFetal and pediatric pathology (Fetal Pediatr Pathol) Vol. 31 Issue 2 Pg. 74-86 (Apr 2012) ISSN: 1551-3823 [Electronic] England
PMID22409407 (Publication Type: Journal Article)
Topics
  • Autopsy
  • Humans
  • Lung (abnormalities)
  • Lung Diseases (congenital)
  • Retrospective Studies

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