Abstract | OBJECTIVE: To evaluate whether a brief course of treatment with gallium nitrate can reduce biochemical parameters of accelerated bone turnover in patients with advanced Paget disease. DESIGN: SETTING: PATIENTS: INTERVENTIONS: RESULTS: Fifteen courses of treatment were administered to ten patients. Reductions in serum alkaline phosphatase and urinary hydroxyproline excretion were observed after treatment with each dose schedule. After treatment with high, intermediate, and low doses, the median maximum decreases in serum alkaline phosphatase activity were 49%, 39%, and 18%, respectively. The median maximum decreases in urinary hydroxyproline excretion were 50%, 52%, and 16%, respectively. The maximum decrease in urinary hydroxyproline excretion occurred within a median of 2 weeks from the start of treatment, whereas the maximum decrease in serum alkaline phosphatase activity occurred substantially later at a median of 6 weeks. All treatment schedules were well tolerated. Response duration was highly variable (range, 6 to 42 weeks). CONCLUSIONS: Short-term treatment with gallium nitrate can reduce biochemical parameters of disease activity in patients with advanced Paget disease of bone. Larger trials using low-dose intermittent treatment schedules are required to evaluate the safety and effectiveness of this therapy.
|
Authors | R P Warrell Jr, B Bosco, S Weinerman, B Levine, J Lane, R S Bockman |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 113
Issue 11
Pg. 847-51
(Dec 01 1990)
ISSN: 0003-4819 [Print] United States |
PMID | 2240900
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
- Creatinine
- Gallium
- Alkaline Phosphatase
- Hydroxyproline
- gallium nitrate
|
Topics |
- Aged
- Alkaline Phosphatase
(blood)
- Creatinine
(urine)
- Dose-Response Relationship, Drug
- Female
- Gallium
(administration & dosage, therapeutic use)
- Humans
- Hydroxyproline
(urine)
- Infusions, Intravenous
- Injections, Subcutaneous
- Male
- Middle Aged
- Osteitis Deformans
(drug therapy, metabolism)
|