Abstract | INTRODUCTION: AIMS: We present four patients with severe TEN (all with >80% involvement of body surface) who were treated with TPE following unsuccessful treatment with corticosteroids/ IVIG. METHODS: RESULTS: The mean number of TPE sessions was 5.25 ± 2.22 (range 3-8). Drugs were implicated as an etiologic agent in each case. TPE led to prompt improvement of acute condition and general health as well as halting of disease progression. Additionally, the restoration of the epithelium began in all four patients. CONCLUSION:
Plasmapheresis should be considered as an alternative treatment modality for patients with the most severe form of TEN if initial treatment with other agents, including corticosteroids and/or IVIG, fails. Drugs were suspected to be the cause of TEN in all four cases.
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Authors | Milan Koštál, Milan Bláha, Miriam Lánská, Marie Koštálová, Vladimír Bláha, Eva Štepánová, Jaroslav Malý |
Journal | Journal of clinical apheresis
(J Clin Apher)
Vol. 27
Issue 4
Pg. 215-20
( 2012)
ISSN: 1098-1101 [Electronic] United States |
PMID | 22407895
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Wiley Periodicals, Inc. |
Chemical References |
- Adrenal Cortex Hormones
- Immunoglobulins, Intravenous
|
Topics |
- Adolescent
- Adrenal Cortex Hormones
(therapeutic use)
- Adult
- Female
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Male
- Middle Aged
- Plasma Exchange
- Plasmapheresis
- Skin
(pathology)
- Stevens-Johnson Syndrome
(pathology, therapy)
- Treatment Outcome
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