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Survey of the feline leukemia virus infection status of cats in Southern Germany.

Abstract
Most studies that investigate the prevalence of infections with feline leukemia virus (FeLV) are based on the detection of p27 antigen in blood, but they do not detect proviral DNA to identify the prevalence of regressive FeLV infections. The aim of the present study was to assess the prevalence and status of FeLV infection in cats in Southern Germany. P27 antigen enzyme-linked immunosorbent assay (ELISA), anti-p45 antibody ELISA, DNA polymerase chain reaction (PCR) of blood and RNA PCR of saliva were performed. Nine out of 495 cats were progressively (persistently) infected (1.8%) and six were regressively (latently) infected (1.2%). Cats with regressive infections are defined as cats that have been able to overcome antigenemia but provirus can be detected by PCR. Twenty-two unvaccinated cats likely had abortive infections (regressor cats), testing FeLV antigen- and provirus-negative but anti-p45 antibody-positive. Most of the FeLV-vaccinated cats did not have anti-FeLV antibodies. Both progressive, as well as regressive infections seem to be rare in Germany today.
AuthorsTheresa Englert, Hans Lutz, Carola Sauter-Louis, Katrin Hartmann
JournalJournal of feline medicine and surgery (J Feline Med Surg) Vol. 14 Issue 6 Pg. 392-8 (Jun 2012) ISSN: 1532-2750 [Electronic] England
PMID22403413 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Viral
  • DNA, Viral
  • Proliferating Cell Nuclear Antigen
  • p27 antigen
Topics
  • Animals
  • Antibodies, Viral (blood)
  • Cat Diseases (epidemiology, virology)
  • Cats
  • DNA, Viral (blood)
  • Enzyme-Linked Immunosorbent Assay (methods, veterinary)
  • Germany (epidemiology)
  • Leukemia Virus, Feline (immunology, isolation & purification)
  • Polymerase Chain Reaction (methods, veterinary)
  • Prevalence
  • Proliferating Cell Nuclear Antigen (blood)
  • Retroviridae Infections (epidemiology, veterinary, virology)
  • Saliva (virology)
  • Tumor Virus Infections (epidemiology, veterinary, virology)

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