Dengue hemorrhagic fever in Trinidad and Tobago: a case for a conservative approach to platelet transfusion.

Abstract

Dengue fever is endemic to Trinidad and Tobago. A retrospective analysis of all adult admissions at a tertiary hospital in Trinidad treated for dengue during January 1-December 31, 2008 was performed. A total of 186 patients were treated during this period: 98.9% (184) of the patients were thrombocytopenic; 45.2% were severely thrombocytopenic; 13 patients showed development of minor hemorrhage and only one case of major hemorrhage; platelet transfusion was given for 7% (13) of the cases; and 6 cases for which platelet transfusion was given did not show evidence of plasma leakage (12 of these cases did not show evidence of hemorrhage). There was a strong association between the lowest platelet value and hemoconcentration (χ(2) = 13.16, P < 0.025). No association was found between giving a platelet transfusion and hemoconcentration or hemorrhage. Thrombocytopenia seen in dengue resolves spontaneously and independent of any transfusion used.

• Authors: Anu Sharma, Kenneth Charles, Dave Chadee, Surujpaul Teelucksingh
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 86 Issue 3 Pg. 531-5 (Mar 2012) ISSN: 1476-1645 [Electronic] United States
• PMID: 22403331 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Female
• Hemorrhage (blood, pathology, therapy)
• Humans
• Male
• Middle Aged
• Platelet Transfusion (methods)
• Retrospective Studies
• Severe Dengue (epidemiology, therapy)
• Thrombocytopenia (blood, pathology, therapy)
• Trinidad and Tobago (epidemiology)
• Young Adult