Abstract | BACKGROUND AND AIMS: METHODS: Terminal ileal tissue from small or large bowel Crohn's disease and normal controls was analysed for enteroendocrine marker expression by immunohistochemistry and quantitative polymerase chain reaction. Inflammation was graded by endoscopic, clinical, histological and biochemical scoring. RESULTS: CONCLUSIONS: Enhanced enteroendocrine cell activity is present in small bowel disease, and observed in restricted cell lineages. This may impact on the epithelial immune response, cellular homeostasis and nutrient handling and influence appetite via increased satiety signalling in the gut-brain axis.
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Authors | Gordon W Moran, Joanne Pennock, John T McLaughlin |
Journal | Journal of Crohn's & colitis
(J Crohns Colitis)
Vol. 6
Issue 9
Pg. 871-80
(Oct 2012)
ISSN: 1876-4479 [Electronic] England |
PMID | 22398079
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- Chromogranin A
- Homeodomain Proteins
- NBPhox protein
- RNA, Messenger
- Transcription Factors
- Peptide YY
- Glucagon-Like Peptide 1
- UBE4A protein, human
- Ubiquitin-Protein Ligases
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Topics |
- Adult
- Aged
- Biomarkers
- Chromogranin A
(genetics, metabolism)
- Crohn Disease
(genetics, metabolism, pathology)
- Enteroendocrine Cells
(cytology, metabolism)
- Gene Expression
- Glucagon-Like Peptide 1
(genetics, metabolism)
- Homeodomain Proteins
(genetics, metabolism)
- Humans
- Ileum
(cytology, metabolism)
- Male
- Middle Aged
- Peptide YY
(metabolism)
- RNA, Messenger
(metabolism)
- Severity of Illness Index
- Statistics, Nonparametric
- Transcription Factors
(genetics, metabolism)
- Ubiquitin-Protein Ligases
(genetics)
- Young Adult
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