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Comparison between topical honey and mafenide acetate in treatment of burn wounds.

Abstract
Histological and clinical studies of wound healing were performed in comparable cases of fresh partial-thickness burns treated with honey dressing or mafenide acetate in two groups of 50 randomly allocated patients. Of the patients with honey-treated wounds, 84% showed satisfactory epithelialization by day 7 and 100% by day 21. In wounds treated with mafenide acetate, epithelialization occurred by day 7 in 72% of cases and in 84% by day 21. Histological evidence of reparative activity was observed in 80% of wounds treated with honey dressing by day 7 with minimal inflammation. Fifty-two per cent of the mafenide acetate treated wounds showed reparative activity with inflammatory changes by day 7. Reparative activity reached 100% by day 21 with the honey dressing and 84% with mafenide acetate. Thus, in honey-dressed wounds, early subsidence of acute inflammatory changes, better control of infection, and quicker wound healing were observed, while in mafenide acetate treated wounds a sustained inflammatory reaction was noted even on epithelialization.
AuthorsH Maghsoudi, F Salehi, M K Khosrowshahi, M Baghaei, M Nasirzadeh, R Shams
JournalAnnals of burns and fire disasters (Ann Burns Fire Disasters) Vol. 24 Issue 3 Pg. 132-7 (Sep 30 2011) ISSN: 1592-9566 [Electronic] Italy
PMID22396671 (Publication Type: Journal Article)

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