Vascular endothelial growth factor receptor 2 gene polymorphisms as predictors for tumor recurrence and overall survival in non-small-cell lung cancer.

Abstract

PURPOSE:

VEGFR-2 gene displays several functional germline polymorphisms with impact on VEGFR-2 mediated angiogenesis. Our purpose was to evaluate VEGFR-2 polymorphisms as prognostic markers for tumor recurrence and overall survival (OS) in non-small-cell lung cancer (NSCLC).

METHODS:

In total, 209 Caucasian patients who had been surgically treated for NSCLC between 1996 and 2010 were included in this study. Genotyping of peripheral blood cells was performed by TaqMan® genotyping assays or polymerase chain reaction for five VEGFR-2 polymorphisms. Chi- square test, Kaplan-Meier estimator, and Cox regression hazard model were used to assess the prognostic value of VEGFR-2 polymorphisms.

RESULTS:

VEGFR-2+4422 (AC)10-14 polymorphism was identified as a positive prognostic marker for time to metastasis (11/12 vs. 11/11 (AC) repeats: hazard ratio (HR), 0.28; 95% confidence interval (CI), 0.11-0.75; p=0.012) and OS (11/12 vs. 11/11 (AC) repeats: HR, 0.41; 95% CI, 0.21-0.82; p=0.012) in squamous cell carcinoma. For adenocarcinoma, VEGFR-2-906 C>T (C/T vs. CC: HR, 0.19; 95% CI, 0.43-0.82; p=0.027) and VEGFR-2-271 G>A (G/A vs. G/G: HR, 0.25; 95% CI, 0.07-0.86; p=0.027) predicted longer time to local recurrence and VEGFR-2-906 C>T was a predictor for better OS (T/T vs. C/C: HR, 0.28; 95% CI, 0.09-0.84; p=0.024).

CONCLUSIONS:

VEGFR2 germline polymorphisms predict tumor recurrence and OS in NSCLC.

• Authors: Faik G Uzunoglu, Caroline Kaufmann, Harriet Wikman, Cenap Güngör, Benjamin A Bohn, Michael F Nentwich, Matthias Reeh, Klaus Pantel, Maximilian Bockhorn, Asad Kutup, Oliver Mann, Jakob R Izbicki, Yogesh K Vashist
• Journal: Annals of surgical oncology (Ann Surg Oncol) Vol. 19 Issue 7 Pg. 2159-68 (Jul 2012) ISSN: 1534-4681 [Electronic] United States
• PMID: 22395975 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Vascular Endothelial Growth Factor Receptor-2

Topics

• Adenocarcinoma (genetics, mortality, secondary)
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (genetics)
• Carcinoma, Non-Small-Cell Lung (genetics, mortality, secondary)
• Carcinoma, Squamous Cell (genetics, mortality, secondary)
• Female
• Follow-Up Studies
• Genotype
• Humans
• Lung Neoplasms (genetics, mortality, pathology)
• Male
• Middle Aged
• Neoplasm Recurrence, Local (genetics, mortality, pathology)
• Neoplasm Staging
• Polymorphism, Genetic (genetics)
• Prognosis
• Prospective Studies
• Risk Factors
• Survival Rate
• Vascular Endothelial Growth Factor Receptor-2 (genetics)