Abstract |
The aim of the present study was to evaluate the impact of the UCP2-866 G/A polymorphism on the efficacy of repaglinide in treating patients with diabetes mellitus type 2 (T2DM). 370 patients with T2DM and 166 healthy volunteers were enrolled to identify UCP2-866 G/A genotypes. 16 patients with GG genotype, 14 with GA genotype and 11 with AA genotype of UCP2-866 G/A underwent an 8-week repaglinide treatment regimen. There were no differences in allele frequency of UCP2-866 G/A between T2DM patients and control subjects. The patient with AA genotype of UCP2-866 G/A had higher levels of fasting plasma glucose (FPG), 30-min and 2-h postload plasma glucose, glycated haemoglobin (HbA1c), and lower concentrations of 30-min and 2-h postload plasma insulin, homeostasis model assessment of beta cell function (HOMA-beta), deltaI30/deltaG30 compared with GG genotype. After repaglinide treatment for 8 consecutive weeks, we found that A allele carriers of UCP2 in the T2DM patients had smaller decrease in FPG (P < 0.05) and HbA1c (P < 0.05), and smaller increase in 30-min postload plasma insulin (P < 0.01) compared with GG genotypes. We demonstrated that UCP2-866 G/A polymorphism is associated with the therapeutic efficacy of repaglinide in Chinese T2DM patients.
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Authors | Shan Wang, Yan-Mei Se, Zhao-Qian Liu, Ming-Xiang Lei, Hao-BoYang, Zhi-Xiang Sun, Sheng-Dan Nie, Xiao-min Zeng, Jing Wu |
Journal | Die Pharmazie
(Pharmazie)
Vol. 67
Issue 1
Pg. 74-9
(Jan 2012)
ISSN: 0031-7144 [Print] Germany |
PMID | 22393835
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Carbamates
- DNA Primers
- Hypoglycemic Agents
- Insulin
- Ion Channels
- Mitochondrial Proteins
- Piperidines
- UCP2 protein, human
- Uncoupling Protein 2
- repaglinide
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Topics |
- Adult
- Aged
- Alleles
- Asian People
(genetics)
- Blood Glucose
(metabolism)
- Carbamates
(pharmacology)
- DNA Primers
- Diabetes Mellitus, Type 2
(drug therapy, genetics)
- Female
- Genotype
- Humans
- Hypoglycemic Agents
(pharmacology)
- Insulin
(blood)
- Insulin-Secreting Cells
(physiology)
- Ion Channels
(genetics)
- Male
- Middle Aged
- Mitochondrial Proteins
(genetics)
- Pancreatic Function Tests
- Piperidines
(pharmacology)
- Polymerase Chain Reaction
- Uncoupling Protein 2
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