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Optical coherence tomography evaluation of in-stent restenotic lesions with visible microvessels.

AbstractOBJECTIVE:
We sought to evaluate the characteristics of in-stent restenosis (ISR) lesions with microvessels, detected by an optical coherence tomography (OCT).
BACKGROUND:
No sufficient in vivo data exist regarding microvessel characteristics in ISR lesions.
METHODS:
Among 78 ISR lesions (drug-eluting stent, n = 72; bare-metal stent, n = 6) in our OCT registry database, visible microvessels were detected in 21 (27%). Microvessels were defined as low backscattering structures <200 μm in diameter on OCT. Clinical, angiographic, and OCT findings were compared between lesions with and without microvessels.
RESULTS:
Lesions with microvessels had a larger reference vessel diameter (2.90 ± 0.47 mm vs 2.58 ± 0.42 mm; P=.009) and post-stent minimum lumen diameter (2.76 ± 0.29 mm vs 2.54 ± 0.39 mm; P=.033) than those without microvessels. From OCT findings at the segment with minimal lumen cross-sectional area (CSA), neointimal hyperplasia (NIH) CSA (5.4 ± 1.7 mm² vs 4.2 ± 2.1 mm²; P=.024) and percent NIH CSA (NIH CSA x 100/stent CSA) were significantly greater in lesions with microvessels (79 ± 12% vs 67 ± 16%; P=.001). On multivariate analysis, reference vessel diameter (odds ratio [OR], 4.64; 95% confidence interval [CI], 1.05-20.4; P=.043) and percent NIH CSA at the segment with minimal lumen CSA (OR, 1.06; 95% CI, 1.01-1.12; P=.021) were independent predictors of microvessels. From receiver operating characteristic analysis, the cut-off values of reference vessel diameter and percent NIH CSA predicting the presence of microvessels were 3.1 mm and 74%, respectively.
CONCLUSIONS:
Visible microvessels in ISR lesions might be associated with increased vessel size and extent of NIH.
AuthorsByeong-Keuk Kim, Jung-Sun Kim, Dong-Ho Shin, Young-Guk Ko, Donghoon Choi, Yangsoo Jang, Myeong-Ki Hong
JournalThe Journal of invasive cardiology (J Invasive Cardiol) Vol. 24 Issue 3 Pg. 116-20 (Mar 2012) ISSN: 1557-2501 [Electronic] United States
PMID22388303 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Aged
  • Angioplasty, Balloon, Coronary
  • Coronary Restenosis (pathology)
  • Coronary Stenosis (therapy)
  • Coronary Vessels (pathology)
  • Drug-Eluting Stents
  • Female
  • Humans
  • Logistic Models
  • Male
  • Microvessels (pathology)
  • Middle Aged
  • Neointima (pathology)
  • ROC Curve
  • Stents
  • Tomography, Optical Coherence (methods)

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