Is the fear of dioxin cancer more harmful than dioxin?

Abstract

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a proven animal carcinogen. Occupational cohorts with the highest exposures imply that there is a small risk of all cancers combined, but it is difficult to pinpoint the confounding effect of the main chemicals. Studies after major accidents do not unequivocally confirm this risk. The risks to populations at the current dioxin levels seem trivial if present at all. There is increasing evidence that the aryl hydrocarbon receptor (AhR), i.e. the so called "dioxin receptor", is a physiological transcription factor exerting important functions in the body. Consequently a certain level of AhR activation may be beneficial rather than harmful. This challenges the wisdom of excessive regulation of dioxin levels in certain foods and nutrients. This could pose indirect nutritional risks, in fact being more harmful than even the worst case predictions of the putative cancer risks attributable to dioxins.

• Authors: Jouko Tuomisto, Jouni T Tuomisto
• Journal: Toxicology letters (Toxicol Lett) Vol. 210 Issue 3 Pg. 338-44 (May 05 2012) ISSN: 1879-3169 [Electronic] Netherlands
• PMID: 22387160 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Dioxins
• Polychlorinated Dibenzodioxins
• Receptors, Aryl Hydrocarbon

Topics

• Animals
• Dioxins (toxicity)
• Dose-Response Relationship, Drug
• Humans
• Neoplasms (chemically induced)
• Polychlorinated Dibenzodioxins (toxicity)
• Receptors, Aryl Hydrocarbon (physiology)
• Risk
• Sarcoma (chemically induced)