Immunogenicity of a Haemophilus influenzae type b-tetanus conjugate vaccine when administered separately or in combined vaccines for primary immunization in two consecutive national schedules in Turkey.

Abstract

BACKGROUND:

In Turkey, the Haemophilus influenzae type b-tetanus toxoid conjugate vaccine (Hib) was replaced by the combined diphtheria-tetanus-acellular pertussis and inactivated polio vaccine (DTaP-IPV/Hib) in 2008. This shift to the new schedule created different cohorts of vaccinated children as a consequence of the different schedules used. We evaluated the immunogenicity of the Hib vaccine in infants vaccinated with these different schedules.

METHODS:

Three groups of children were evaluated: group 1 comprised 145 infants vaccinated with diphtheria, tetanus, and whole cell pertussis (DTwP), oral polio vaccine (OPV), and Hib vaccines simultaneously at separate sites; group 2 comprised 204 infants vaccinated with the DTaP-IPV/Hib combined vaccine; group 3 comprised 100 infants vaccinated with a mixed schedule of DTwP, OPV, and Hib for the first one or two doses, followed by DTaP-IPV/Hib vaccine to complete the series.

RESULTS:

Anti-polyribosylribitol phosphate (anti-PRP) titers ≥0.15μg/ml were similar in groups 1, 2, and 3. However, in group 1, who received all the vaccines at separate sites, ≥ l.0μg/ml long-lasting antibody titers and anti-PRP geometric mean titers were higher (p=0.001).

CONCLUSION:

This study showed that even one dose administered in combination with other vaccines in a primary series decreased the level of anti-PRP.

• Authors: Nurullah Yüksel, Ufuk Beyazova, Işil Fidan Balci, Fatma Nur Aksakal, Aysu Duyan Camurdan, Figen Sahin, Seyyal Rota
• Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases (Int J Infect Dis) Vol. 16 Issue 5 Pg. e354-7 (May 2012) ISSN: 1878-3511 [Electronic] Canada
• PMID: 22387144 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Antibodies, Bacterial
• Diphtheria Toxoid
• Haemophilus Vaccines
• Pertussis Vaccine
• Poliovirus Vaccine, Inactivated
• Polysaccharides
• Tetanus Toxoid
• Vaccines, Acellular
• Vaccines, Combined
• polyribitol phosphate

Topics

• Antibodies, Bacterial (blood)
• Diphtheria Toxoid (administration & dosage)
• Haemophilus Infections (prevention & control)
• Haemophilus Vaccines (administration & dosage, immunology)
• Haemophilus influenzae type b (immunology)
• Humans
• Infant
• Mass Vaccination
• Pertussis Vaccine (administration & dosage)
• Poliovirus Vaccine, Inactivated (administration & dosage)
• Polysaccharides (immunology)
• Population Surveillance
• Tetanus Toxoid (administration & dosage)
• Turkey
• Vaccines, Acellular (administration & dosage)
• Vaccines, Combined (administration & dosage, immunology)