Abstract | BACKGROUND:
Fever is the most common precipitant of status epilepticus in children. Animal models suggest that only γ-aminobutyric acidic drugs are effective in the treatment of febrile seizures, but there is limited clinical evidence to support this. OBJECTIVE: METHODS: This study is a retrospective chart review of 56 children (62 episodes) who presented to our emergency department with febrile status epilepticus and received phenytoin. The clinical parameters were evaluated by reviewing the charts. The efficacy of phenytoin was classified into 3 categories: positive, negative, and nonevaluable response. RESULTS: The primary outcome was to evaluate the efficacy rate of phenytoin; there were 9 (14.5%) of 62 episodes with a positive response, 25 (40.3%) with a negative response, and 28 (45.2%) with a nonevaluable response because phenytoin was given simultaneously with a γ-aminobutyric acidic (GABAergic) drug (P < .001). The secondary outcome was to measure the mean seizure duration for each treatment category, which were 52.8, 109.9, and 52.6 minutes, respectively (P < .01). CONCLUSION:
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Authors | Salima Ismail, Arielle Lévy, Helena Tikkanen, Marcel Sévère, Franciscus Johannes Wolters, Lionel Carmant |
Journal | The American journal of emergency medicine
(Am J Emerg Med)
Vol. 30
Issue 9
Pg. 2000-4
(Nov 2012)
ISSN: 1532-8171 [Electronic] United States |
PMID | 22381577
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Anticonvulsants
- Phenytoin
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Topics |
- Anticonvulsants
(therapeutic use)
- Emergency Service, Hospital
- Humans
- Infant
- Male
- Phenytoin
(therapeutic use)
- Retrospective Studies
- Seizures, Febrile
(drug therapy)
- Status Epilepticus
(drug therapy)
- Treatment Outcome
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