[Keratin 8 expression in mouth mucosa hyperkeratosis and squamous cell carcinoma ].

Abstract

The immunohistochemical study of proliferation and intermediate filament--keratin 8 expressions at oral hyperkeratosis and oral Squamous cell carcinoma (OSCC) has been carried out. It has been shown, that the specific character of keratin 8 expressions can be used in differential diagnosis between oral hyperkeratosis and OSCC. Different types of oral hyperkeratosis (without atypia, SIN1, SIN2 and SIN3) can be differentiated by Ki-67 and keratin 8. We have found the moderate positive correlation between proliferation and a keratin 8 expression in neoplastic epithelial cells.

• Authors: I I Babichenko, A S Grigor'ian, A A Katushkina
• Journal: Arkhiv patologii (Arkh Patol) 2011 Nov-Dec Vol. 73 Issue 6 Pg. 18-21 ISSN: 0004-1955 [Print] Russia (Federation)
• PMID: 22379894 (Publication Type: English Abstract, Journal Article)

Chemical References

• Biomarkers, Tumor
• KRT8 protein, human
• Keratin-8
• Ki-67 Antigen

Topics

• Biomarkers, Tumor (biosynthesis, genetics)
• Carcinoma, Squamous Cell (diagnosis, metabolism, pathology)
• Cell Proliferation
• Diagnosis, Differential
• Epithelial Cells (metabolism, pathology)
• Female
• Humans
• Immunohistochemistry
• Keratin-8 (biosynthesis, genetics)
• Ki-67 Antigen (biosynthesis)
• Leukoplakia, Oral (diagnosis, metabolism, pathology)
• Male
• Middle Aged
• Mouth Mucosa (metabolism, pathology)
• Mouth Neoplasms (diagnosis, metabolism, pathology)