Abstract | BACKGROUND: PURPOSE: METHODS: Samples were collected from 12 premenopausal women admitted for abdominal hysterectomy due to fibroids. RESULTS: The protein expression of ERα, ERβ and aromatase was similar in leiomyoma and normal myometrium (p = 0.239, p = 0.695 and p = 0.203, respectively). CONCLUSIONS: In this analysis of 12 matched leiomyoma and myometrial samples, the data do not support the theory that overexpression ERα, ERβ and aromatase in uterine leiomyomas compared to adjacent myometrium are the cause of tumor growth. The estrogens may exert their growth-stimulatory effects on leiomyomas intermediated by other elements, such as cytokines and growth or apoptosis factors. The effect of estrogen on the growth and development of fibroids is complex and far from being completely understood.
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Authors | Anelise Olmos Grings, Vanessa Lora, Gustavo Dias Ferreira, Ilma Simoni Brum, Helena von Eye Corleta, Edison Capp |
Journal | Gynecologic and obstetric investigation
(Gynecol Obstet Invest)
Vol. 73
Issue 2
Pg. 113-7
( 2012)
ISSN: 1423-002X [Electronic] Switzerland |
PMID | 22377971
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 S. Karger AG, Basel. |
Chemical References |
- ESR1 protein, human
- Estrogen Receptor alpha
- Estrogen Receptor beta
- Aromatase
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Topics |
- Adult
- Aromatase
(genetics, metabolism)
- Blotting, Western
- Estrogen Receptor alpha
(genetics, metabolism)
- Estrogen Receptor beta
(genetics, metabolism)
- Female
- Gene Expression
- Humans
- Hysterectomy
- Leiomyoma
(metabolism, surgery)
- Middle Aged
- Myometrium
(metabolism)
- Premenopause
- Uterine Neoplasms
(metabolism, surgery)
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