Abstract | AIM: METHODS: RESULT: (1) At the 4th, 8th and 12th week, the areas of RIF were significantly increased in D and T groups, which was accompanied by higher levels of 24-h urinary protein, Scr, HIF-1α, ET-1 and TIMP-1 compared with C group. (2) At the 8th and 12th week, the above changes were significantly attenuated in T group compared with D group. CONCLUSIONS:
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Authors | Lin Tang, Run Yi, Bing Yang, Hui Li, Huijuan Chen, Zhangsuo Liu |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 97
Issue 1
Pg. 125-31
(Jul 2012)
ISSN: 1872-8227 [Electronic] Ireland |
PMID | 22377232
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Blood Glucose
- Endothelin-1
- Hif1a protein, rat
- Hypoxia-Inducible Factor 1, alpha Subunit
- Tetrazoles
- Tissue Inhibitor of Metalloproteinase-1
- Streptozocin
- Valsartan
- Creatinine
- Valine
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Topics |
- Animals
- Blood Glucose
(metabolism)
- Blotting, Western
- Creatinine
(blood)
- Diabetes Mellitus, Experimental
(drug therapy, pathology)
- Diabetic Nephropathies
(drug therapy, pathology)
- Endothelin-1
(metabolism)
- Gene Expression
- Hypoxia-Inducible Factor 1, alpha Subunit
(antagonists & inhibitors, metabolism)
- Immunohistochemistry
- Kidney
(drug effects, pathology)
- Male
- Nephritis, Interstitial
(drug therapy, pathology)
- Proteinuria
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Real-Time Polymerase Chain Reaction
- Streptozocin
- Tetrazoles
(pharmacology)
- Tissue Inhibitor of Metalloproteinase-1
(metabolism)
- Valine
(analogs & derivatives, pharmacology)
- Valsartan
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