HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hematopoietic MyD88-adaptor protein acts as a natural defense mechanism for cognitive deficits in Alzheimer's disease.

Abstract
Accumulating evidence supports a critical role of Toll-like receptors in the clearance of Amyloid beta (Aβ) by microglial cells. Myeloid differentiation factor 88 (MyD88) is an adaptor protein that bridges the intracellular signal to nucleus for most of these innate immune receptors. We investigated here the role of competent MyD88 hematopoietic stem cells on the cognitive decline of a mouse model of Alzheimer's disease (AD). We generated classical chimeric mouse models using irradiation and transplantation of wild type GFP cells and MyD88-deficient cells. Transplantation of GFP cells essentially rescued the cognitive impairment, whereas MyD88-deficient cells significantly accelerated memory deficits of APP(swe)/PS1 mice. Moreover, we found that monocytes and microglia deficient for MyD88 exhibit a functionally impaired phagocytic reaction to Aβ.
AuthorsJean-Philippe Michaud, Karine L Richard, Serge Rivest
JournalStem cell reviews and reports (Stem Cell Rev Rep) Vol. 8 Issue 3 Pg. 898-904 (Sep 2012) ISSN: 2629-3277 [Electronic] United States
PMID22374079 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amyloid
  • Amyloid beta-Peptides
  • Myd88 protein, mouse
  • Myeloid Differentiation Factor 88
Topics
  • Alzheimer Disease (immunology, metabolism, pathology)
  • Amyloid (metabolism)
  • Amyloid beta-Peptides (metabolism)
  • Animals
  • Bone Marrow Transplantation
  • Cells, Cultured
  • Cognition
  • Cognition Disorders (immunology, metabolism, pathology)
  • Immunity, Innate
  • Maze Learning
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Microglia (metabolism, physiology)
  • Myeloid Differentiation Factor 88 (deficiency, genetics, physiology)
  • Phagocytosis
  • Signal Transduction

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: