Fractional photothermolysis (FP)
therapy and chemical peels have been reported to be effective in patients with recalcitrant
melasma. However, there is little information to compare the efficacy of single treatment session in Asian women. The aim of this study was to examine the efficacy, long-lasting outcomes and safety of a single session of 1550-nm
erbium-doped FP in Asian patients, compared with
trichloroacetic acid (TCA) peel with a medium depth. Eighteen Korean women (Fitzpatrick skin type III or IV) with moderate-to-severe bilateral
melasma were randomly treated with a single session of 1550-nm FP on one cheek, and with a 15% TCA peel on the other cheek. Outcome measures included an objective
melasma area severity index and subjective patient-rated overall improvement at 4 and 12 weeks
after treatment.
Melasma lesions were significantly improved 4 weeks after either treatment, but
melasma recurred at 12 weeks. Post-inflammatory
hyperpigmentation developed in 28% of patients at 4 weeks but resolved in all but one patient by 12 weeks. There was no difference between FP treatment and TCA peeling with respect to any outcome measure. FP
laser and TCA peel treatments were equally effective and safe when used to treat moderate-to-severe
melasma, but neither treatment was long-lasting. We suggest that multiple or periodic maintenance treatments and/or supplemental procedures may be required for the successful treatment of
melasma in Asian women.