[Cutaneous necrosis at the initiation of antivitamin K treatment disclosing hereditary protein C deficiency].

Abstract

We report the case of a 57-year old woman whose severe protein C deficiency was revealed soon after oral anticoagulants were introduced into her treatment. Two previous episodes of deep leg vein thrombosis followed by a third episode with suspicion of embolus migration had led to treatment with heparin later replaced by oral anticoagulants. On the 4th day of anticoagulant therapy, she developed skin necrosis of the left calf. A protein C assay showed severe deficiency (19% level as compared with the 70-120% normal levels). The main causes of acquired protein C deficiency were excluded. The first results of a family study demonstrated moderate protein C deficiency in a 30-year old, asymptomatic daughter.

• Authors: M Piffoux, F Tcherakian, S Tcherakian, M H Horellou
• Journal: Revue de pneumologie clinique (Rev Pneumol Clin) Vol. 46 Issue 3 Pg. 125-7 ( 1990) ISSN: 0761-8417 [Print] France
• Vernacular Title: Nécrose cutanée à l'introduction des antivitamines K révélatrice d'un déficit constitutionnel en protéine C.
• PMID: 2237146 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Anticoagulants
• Vitamin K

Topics

• Adult
• Anticoagulants (adverse effects)
• Deficiency Diseases (genetics)
• Female
• Humans
• Leg
• Middle Aged
• Necrosis (chemically induced)
• Protein C Deficiency
• Skin (pathology)
• Thromboembolism (blood, etiology)
• Vitamin K (antagonists & inhibitors)