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[Effects of jingqianshu granule on expression of 5-HT(1A)R of PMS model rats with liver-qi stagnation].

AbstractOBJECTIVE:
To research the effect of the Jingqianshu granule (JQS) on the expression of serotonin receptor-1A (5-HT(1A)R) in hippocampus and hypothalamus of premenstrual syndrome (PMS) model rats with Liver-qi depression.
METHOD:
The PMS model rats with Liver-qi depression were induced by bandaging the limbs. The model rats were treated with JQS, and evaluated by open-field test. The expression of 5-HT(1A)R in hippocampus and hypothalamus was analysed by the method of RT-PCR and Western blot.
RESULT:
After the JQS were administered, the open field scores, the expression of 5-HT(1A)R mRNA and protein in hippocampus and hypothalamus of rats increased significantly.
CONCLUSION:
The JQS granule can up-regulate the expression of 5-HT(1A)R in hippocampus and hypothalamus, which maybe one of the mechanism to treat PMS with liver-qi depression.
AuthorsYunxiang Su, Ling Xue
JournalZhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 36 Issue 24 Pg. 3498-501 (Dec 2011) ISSN: 1001-5302 [Print] China
PMID22368865 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drugs, Chinese Herbal
  • Receptor, Serotonin, 5-HT1A
Topics
  • Animals
  • Disease Models, Animal
  • Drugs, Chinese Herbal (pharmacology, therapeutic use)
  • Female
  • Liver Diseases (drug therapy, metabolism)
  • Premenstrual Syndrome (drug therapy, metabolism)
  • Qi
  • Rats
  • Receptor, Serotonin, 5-HT1A (analysis)

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