Abstract | OBJECTIVE: To research the effect of the Jingqianshu granule (JQS) on the expression of serotonin receptor-1A (5-HT(1A)R) in hippocampus and hypothalamus of premenstrual syndrome (PMS) model rats with Liver-qi depression. METHOD: The PMS model rats with Liver-qi depression were induced by bandaging the limbs. The model rats were treated with JQS, and evaluated by open-field test. The expression of 5-HT(1A)R in hippocampus and hypothalamus was analysed by the method of RT-PCR and Western blot. RESULT: After the JQS were administered, the open field scores, the expression of 5-HT(1A)R mRNA and protein in hippocampus and hypothalamus of rats increased significantly. CONCLUSION: The JQS granule can up-regulate the expression of 5-HT(1A)R in hippocampus and hypothalamus, which maybe one of the mechanism to treat PMS with liver-qi depression.
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Authors | Yunxiang Su, Ling Xue |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 36
Issue 24
Pg. 3498-501
(Dec 2011)
ISSN: 1001-5302 [Print] China |
PMID | 22368865
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drugs, Chinese Herbal
- Receptor, Serotonin, 5-HT1A
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Topics |
- Animals
- Disease Models, Animal
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Female
- Liver Diseases
(drug therapy, metabolism)
- Premenstrual Syndrome
(drug therapy, metabolism)
- Qi
- Rats
- Receptor, Serotonin, 5-HT1A
(analysis)
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