IL1A-889 C/T gene polymorphism in irritant contact dermatitis.

Abstract

BACKGROUND:

Upon skin contact to irritants, interleukin-1 alpha (IL-1α) is released in the stratum corneum as a primary step of skin inflammation. Variations in the IL-1A gene have been shown to alter the expression of IL-1α. This may influence the susceptibility to skin inflammation and the development of irritant contact dermatitis (ICD).

OBJECTIVE:

To determine effects of an IL1A-889 C/T polymorphism in view of susceptibility to develop irritant contact dermatitis.

METHODS:

In a case-control study, 478 Caucasian patients with occupational ICD of the hands were genotyped for an IL1A-889 C/T polymorphism. Results were compared to 393 apprentices from the same high risk occupations (controls).

RESULTS:

Trends of a protective effect of the C → T transition at position IL1A-889 were seen (OR = 0.81; 95% CI: 0.65-1.00). The genotype distribution for IL1A-889 was 52.2% wild type (C/C), 39.2% heterozygous (C/T) and 8.6% homozygous for variant allele (T/T) in patients and 46.0%, 42.7% and 11.4% in controls. Subgroup analysis, which took into account atopy status and exposure, did not reveal a significant effect of this polymorphism for an aberrant risk to acquire for ICD.

CONCLUSION:

Our study indicates a possible protective effect of the IL1A-889 C/T polymorphism regarding the development of ICD.

• Authors: L Landeck, M Visser, S Kezic, S M John
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 27 Issue 8 Pg. 1040-3 (Aug 2013) ISSN: 1468-3083 [Electronic] England
• PMID: 22364598 (Publication Type: Journal Article)
• Copyright: © 2012 The Authors. Journal of the European Academy of Dermatology and Venereology © 2012 European Academy of Dermatology and Venereology.

Chemical References

• Interleukin-1alpha
• Irritants

Topics

• Dermatitis, Contact (etiology, genetics)
• Humans
• Interleukin-1alpha (genetics)
• Irritants (toxicity)
• Polymorphism, Genetic