Severe vitamin D deficiency in a patient treated for hepatitis B with tenofovir.

Abstract

With the increasing use of tenofovir disoproxil in the management of HIV and hepatitis B, serious adverse effects, such as renal dysfunction, will inevitably increase in frequency. We describe a case of a patient presenting with hypophosphataemia suggestive of Fanconi's syndrome, but in fact explicable by simple vitamin D deficiency. This emphasizes that while monitoring for adverse effects is recommended, physicians must consider all alternative causes for biochemical abnormalities prior to discontinuing tenofovir and delaying appropriate management.

• Authors: N Kumar, M Bower, M Nelson
• Journal: International journal of STD & AIDS (Int J STD AIDS) Vol. 23 Issue 1 Pg. 59-60 (Jan 2012) ISSN: 1758-1052 [Electronic] England
• PMID: 22362693 (Publication Type: Case Reports, Journal Article)

Chemical References

• Organophosphonates
• Reverse Transcriptase Inhibitors
• Tenofovir
• Adenine

Topics

• Adenine (analogs & derivatives, therapeutic use)
• Hepatitis B (blood, complications, drug therapy)
• Humans
• Hypophosphatemia (etiology)
• Male
• Middle Aged
• Organophosphonates (therapeutic use)
• Reverse Transcriptase Inhibitors (therapeutic use)
• Tenofovir
• Vitamin D Deficiency (complications, drug therapy)