Lung transplantation in patients with coal workers' pneumoconiosis.

Abstract

Patients with coal workers' pneumoconiosis (CWP) can develop chronic respiratory failure and require lung transplantation. A retrospective review was performed of the 712 referrals and 143 patients undergoing unilateral or bilateral lung transplantation at the University of Kentucky Medical Center between January 1999 and July 2009. Twenty-one of the 712 referrals (3%) had a diagnosis of CWP with eight patients eventually undergoing lung transplant (six single, two bilateral). The mean age of the cohort was 53 ± 5 (mean ± SD) yr (range 45-59). There was no increased risk of perioperative or postoperative complications. Six patients (75%) remain alive after a mean follow-up of 1013 ± 857 d with the two deaths attributable to sepsis 683 and 145 d after transplant, respectively. There were no pulmonary complications because of the native lung in patients after a single lung transplant, with otherwise good clinical outcomes seen after lung transplantation.

• Authors: Don Hayes Jr, Enrique Diaz-Guzman, Daniel L Davenport, Joseph B Zwischenberger, Mehdi Khosravi, Kimberly J Absher, Charles W Hoopes
• Journal: Clinical transplantation (Clin Transplant) 2012 Jul-Aug Vol. 26 Issue 4 Pg. 629-34 ISSN: 1399-0012 [Electronic] Denmark
• PMID: 22360577 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 John Wiley & Sons A/S.

Topics

• Anthracosis (diagnostic imaging, etiology, mortality, therapy)
• Follow-Up Studies
• Graft Survival
• Humans
• Lung Transplantation
• Male
• Middle Aged
• Occupational Exposure (adverse effects)
• Prognosis
• Retrospective Studies
• Risk Factors
• Survival Rate
• Tomography, X-Ray Computed