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Activity of ceftaroline against serotyped Streptococcus pneumoniae isolates from Europe and South Africa associated with community-acquired bacterial pneumonia (2007-08).

AbstractOBJECTIVES:
To determine the activity of ceftaroline (the active metabolite of the prodrug ceftaroline fosamil), a new cephalosporin recently approved in the USA for the treatment of community-acquired bacterial pneumonia, against serotyped Streptococcus pneumoniae causing community-acquired bacterial pneumonia from Europe and South Africa.
METHODS:
During 2007-08, 74 centres submitted 857 isolates of S. pneumoniae from patients with community-acquired bacterial pneumonia. These were re-identified and serotyped. MICs of ceftaroline and 12 comparators were determined by CLSI broth microdilution at a central laboratory.
RESULTS:
Ceftaroline was very active against all 857 S. pneumoniae isolates (MIC(90) 0.12 mg/L). The MIC(50) for South African isolates was 0.06 mg/L compared with 0.004 or 0.008 mg/L for isolates from elsewhere. Antibiotic resistance was also higher in South Africa than other countries. Serotypes 3, 1, 7 and 11 were more susceptible to ceftaroline (MIC(90) = 0.008 mg/L) and the reference antibiotics than the population as a whole. Ceftaroline showed a biphasic MIC distribution (associated with cefuroxime susceptibility), the extent of which differed between isolate populations. Nevertheless, the highest ceftaroline MIC observed was only 0.5 mg/L (two isolates: one from the UK and one from South Africa).
CONCLUSIONS:
These data from a large collection of S. pneumoniae isolates during 2007-08 from Europe and South Africa with varying serotype and antibiotic susceptibility, confirm the excellent in vitro activity of ceftaroline against S. pneumoniae causing community-acquired bacterial pneumonia in both adults and children.
AuthorsIan Morrissey, Anne Leakey
JournalThe Journal of antimicrobial chemotherapy (J Antimicrob Chemother) Vol. 67 Issue 6 Pg. 1408-12 (Jun 2012) ISSN: 1460-2091 [Electronic] England
PMID22357801 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-Bacterial Agents
  • Cephalosporins
  • T 91825
Topics
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents (pharmacology)
  • Cephalosporins (pharmacology)
  • Child
  • Child, Preschool
  • Community-Acquired Infections (microbiology)
  • Europe
  • Female
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Pneumonia, Pneumococcal (microbiology)
  • Serotyping
  • South Africa
  • Streptococcus pneumoniae (classification, isolation & purification)
  • Young Adult

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