Evaluation of WO2011134971, chiral 1,6-napthyridine Syk kinase inhibitors.

Abstract

A small number of novel 7-(1-alkylpyrazol-4-yl)-N-[(4-fluoro-4-piperidyl)methyl]-1,6-naphthyridin-5-amines are claimed. The compounds are Syk kinase inhibitors useful in the treatment of allergic and inflammatory diseases and cancer. They represent another possible development candidate in what has become an increasing area of activity in the search for kinase inhibitors for the treatment of chronic diseases.

• Authors: Peter Norman
• Journal: Expert opinion on therapeutic patents (Expert Opin Ther Pat) Vol. 22 Issue 3 Pg. 335-9 (Mar 2012) ISSN: 1744-7674 [Electronic] England
• PMID: 22356552 (Publication Type: Journal Article)

Chemical References

• Amines
• Intracellular Signaling Peptides and Proteins
• Naphthyridines
• Protein Kinase Inhibitors
• Protein-Tyrosine Kinases
• SYK protein, human
• Syk Kinase

Topics

• Amines (chemistry, pharmacology)
• Animals
• Drug Design
• Humans
• Hypersensitivity (drug therapy, immunology)
• Inflammation (drug therapy, physiopathology)
• Intracellular Signaling Peptides and Proteins (antagonists & inhibitors, metabolism)
• Naphthyridines (chemistry, pharmacology)
• Neoplasms (drug therapy, pathology)
• Patents as Topic
• Protein Kinase Inhibitors (chemistry, pharmacology)
• Protein-Tyrosine Kinases (antagonists & inhibitors, metabolism)
• Syk Kinase