Abstract | INTRODUCTION/AIM: METHODS: Male Albino mice were pretreated intravenously (iv) with increasing doses of oximes and/or memantine (10 mg/kg) at various times before poisoning with 1.3 LD-50 of soman, dichlorvos or heptenophos, in order to determine the median effective dose and the efficacy half-time. In a separate experiment, cerebral extravasation of Evans blue dye (40 mg/kg iv) was examined after application of memantine (10 mg/kg iv), midazolam (2.5 mg/kg intraperitonealy--ip) and ketamine (20 mg/kg ip) 5 minutes before soman (1 LD-50 subcutaneously--sc). RESULTS: CONCLUSION:
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Authors | Biljana Antonijević, Milos P Stojiljković, Dubravko Bokonjić, Slavica Vucinić |
Journal | Vojnosanitetski pregled
(Vojnosanit Pregl)
Vol. 68
Issue 12
Pg. 1033-40
(Dec 2011)
ISSN: 0042-8450 [Print] Serbia |
PMID | 22352264
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Antidotes
- Cholinesterase Reactivators
- Organophosphorus Compounds
- Oximes
- Pyridinium Compounds
- Obidoxime Chloride
- Dichlorvos
- Soman
- asoxime chloride
- heptenophos
- Memantine
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Topics |
- Animals
- Antidotes
(administration & dosage)
- Cholinesterase Reactivators
(administration & dosage)
- Dichlorvos
(poisoning)
- Drug Therapy, Combination
- Male
- Memantine
(administration & dosage)
- Mice
- Obidoxime Chloride
(administration & dosage)
- Organophosphate Poisoning
- Organophosphorus Compounds
- Oximes
(administration & dosage)
- Pyridinium Compounds
(administration & dosage)
- Soman
(poisoning)
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