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[Successful treatment of congenital cytomegalovirus infection with valganciclovir].

Abstract
Congenital cytomegalovirus (CMV) infection occurs frequently in neonates. However, there are no screening tests or definitive treatments for this infection in Japan. We report a case of a 21-day-old Japanese boy with congenital CMV infection. He was referred to our hospital for treatment of congenital bilateral deafness. Brain magnetic resonance imaging (MRI) revealed cortical dysplasia of the temporal poles, enlarged ventricles, and areas of abnormal intensity in the white matter. He was given a diagnosis of congenital CMV infection based on the detection of CMV DNA in his urine and the umbilical cord. After the administration of valganciclovir, no CMV DNA was detected in his serum, and brain MRI and electroencephalogram findings, motor development, and deafness improved. Further investigation is needed to establish a screening test and treatment for congenital CMV infection in Japan.
AuthorsYu Ishida, Tasuku Miyajima, Masaru Shimura, Shinichiro Morichi, Yasuyuki Morishima, Hiroaki Ioi, Shingo Oana, Gaku Yamanaka, Hisashi Kawashima, Akinori Hoshika
JournalNo to hattatsu = Brain and development (No To Hattatsu) Vol. 44 Issue 1 Pg. 55-9 (Jan 2012) ISSN: 0029-0831 [Print] Japan
PMID22352032 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Viral
  • Antiviral Agents
  • Biomarkers
  • DNA, Viral
  • Immunoglobulin M
  • Valganciclovir
  • Ganciclovir
Topics
  • Antibodies, Viral (blood)
  • Antiviral Agents (administration & dosage)
  • Biomarkers (blood, urine)
  • Cytomegalovirus (genetics, immunology)
  • Cytomegalovirus Infections (congenital, diagnosis, drug therapy)
  • DNA, Viral (urine)
  • Electroencephalography
  • Ganciclovir (administration & dosage, analogs & derivatives)
  • Humans
  • Immunoglobulin M (blood)
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Male
  • Treatment Outcome
  • Valganciclovir

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