Abstract | BACKGROUND: Combining ultrasonography, computed tomography (CT), magnetic resonance imaging (MRI) and fine-needle aspiration cytology (FNAC) usually results in the best preoperative diagnosis of cervical masses, including neoplasms. This may not be true, however, especially in occult papillary thyroid carcinoma (PTC) associated with single cystic cervical lymph node metastasis. We assessed the role of thyroglobulin measurement in FNA fluid (FNATg) in differentially diagnosing cystic cervical mass lesions, including PTC cystic lymph node metastasis. METHODS: We reviewed the records of 17 subjects with cervical cystic masses undergoing both FNATg measurement and surgery. FNA was done under ultrasonographic guidance. We also measured FNATg concentrations from extrathyroid lesions, consisting of cystic cervical lymph node metastases and benign cystic lesions. RESULTS: CONCLUSION: High concentrations of FNATg in a cystic cervical mass is considered specific to PTC lymph node metastasis, indicating its usefulness in distinguish PTC cystic metastasis from other cystic lesions. Including FNATg measurement with FNAC may thus improve preoperative diagnosis accuracy without additionally stressing subjects with PTC cystic lymph node metastasis.
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Authors | Yozo Inagaki, Koji Sakamoto, Yasuhiro Inoue, Yorihisa Imanishi, Toshiki Tomita, Seiichi Shinden, Hiroyuki Ozawa, Ryoichi Fujii, Seiji Shigetomi, Takahisa Watabe, Hiroyuki Yamada, Kaoru Ogawa |
Journal | Nihon Jibiinkoka Gakkai kaiho
(Nihon Jibiinkoka Gakkai Kaiho)
Vol. 114
Issue 12
Pg. 912-6
(Dec 2011)
ISSN: 0030-6622 [Print] Japan |
PMID | 22352010
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Biopsy, Fine-Needle
- Carcinoma
- Carcinoma, Papillary
- Female
- Humans
- Lymphatic Metastasis
(diagnosis)
- Male
- Middle Aged
- Neck
- Thyroglobulin
(analysis)
- Thyroid Cancer, Papillary
- Thyroid Neoplasms
(pathology)
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