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A Dermatitis Control Program (DeCoP) for head and neck cancer patients receiving radiotherapy: a prospective phase II study.

AbstractPURPOSE:
We speculated that a systematic program to manage radiation dermatitis might decrease the incidence of severe or fatal cases in head and neck cancer patients receiving radiotherapy. Here, we conducted a prospective phase II study to clarify the clinical benefit of a Dermatitis Control Program (DeCoP) that did not use corticosteroids.
PATIENTS AND METHODS:
Head and neck cancer patients scheduled to receive definitive or postoperative radiotherapy were enrolled. Radiation dermatitis was managed with a DeCoP consisting of a three-step ladder: Step 1, gentle washing; Step 2, gentle washing and moistening of the wound-healing environment; Step 3, prevention against infection, gentle washing and moistening of the wound-healing environment. The primary endpoint was the incidence of grade 4 dermatitis.
RESULTS:
A total of 113 patients were registered between January 2009 and February 2010. Eighty patients received radiotherapy as an initial approach, while the remaining 33 received radiotherapy postoperatively. Grade 3 and 4 dermatitis events occurred in 11 (9.7%) and 0 (0%, 95% confidence interval 0-3.2%) patients, respectively. Median radiation dose at the onset of grade 2 dermatitis was 61.5 Gy (range 36-70 Gy) and median period between onset and recovery was 14 days (range 1-46 days).
CONCLUSION:
The Dermatitis Control Program has promising clinical potential. Radiation dermatitis might be manageable if gentle washing and moistening of the wound-healing environment is done.
AuthorsSadamoto Zenda, Shinobu Ishi, Mitsuhiko Kawashima, Satoko Arahira, Makoto Tahara, Ryuichi Hayashi, Seiji Kishimoto, Tomiko Ichihashi
JournalInternational journal of clinical oncology (Int J Clin Oncol) Vol. 18 Issue 2 Pg. 350-5 (Apr 2013) ISSN: 1437-7772 [Electronic] Japan
PMID22350025 (Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Head and Neck Neoplasms (complications, pathology, radiotherapy)
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Radiation Dosage
  • Radiodermatitis (drug therapy, pathology)
  • Wound Healing

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