[(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX.

Enhanced receptor selectivity: carbonic anhydrase inhibitors are relevant for both cancer diagnosis and therapy. Combining non-radioactive Re compounds with their radioactive (99m)Tc homologs enables the use of identical molecules for therapy and imaging (theragnostic). The syntheses and in vitro evaluation of [(Cp-R)M(CO)(3)] (Cp=cyclopentadienyl, M=Re, (99m)Tc) with R being a highly potent carbonic-anhydrase-targeting vector is reported.
AuthorsDaniel Can, Bernhard Spingler, Paul Schmutz, Filipa Mendes, Paula Raposinho, Célia Fernandes, Fabrizio Carta, Alessio Innocenti, Isabel Santos, Claudiu T Supuran, Roger Alberto
JournalAngewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 51 Issue 14 Pg. 3354-7 (Apr 2 2012) ISSN: 1521-3773 [Electronic] Germany
PMID22344779 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Chemical References
  • Antigens, Neoplasm
  • Carbonic Anhydrase Inhibitors
  • Coordination Complexes
  • Organotechnetium Compounds
  • Sulfonamides
  • Sulfonic Acids
  • Tamoxifen
  • Rhenium
  • sulfamic acid
  • CA9 protein, human
  • Carbonic Anhydrases
  • Antigens, Neoplasm (chemistry, metabolism)
  • Carbonic Anhydrase Inhibitors (chemistry, pharmacology)
  • Carbonic Anhydrases (chemistry, metabolism)
  • Cell Proliferation (drug effects)
  • Coordination Complexes (chemistry, pharmacology)
  • HEK293 Cells
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Organotechnetium Compounds (chemistry)
  • Rhenium (chemistry)
  • Sulfonamides (chemistry)
  • Sulfonic Acids (chemistry)
  • Tamoxifen (chemistry)

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