Carvedilol attenuates oxidative stress in chronic chagasic cardiomyopathy.

Abstract

BACKGROUND:

There is increasing evidence suggesting that Chagas disease involves oxidative damage and contributes to heart disease progression.

OBJECTIVE:

To evaluate the effect of carvedilol on oxidative stress markers in chronic Chagas disease.

METHODS:

The study population included 42 patients with Chagas cardiomyopathy and oxidative stress biomarkers were measured before and after a period of six months of treatment with carvedilol (37.5 mg/day). Patients were considered according to the Los Andes classification and the activity of superoxide dismutase, catalase, glutathione peroxidase, S-transferase and reductase, myeloperoxidase and adenosine deaminase; levels of reduced glutathione, thiobarbituric acid reactive species, carbonyl protein, vitamin E and nitric oxide were measured in blood.

RESULTS:

After treatment with carvedilol, all groups showed significant reductions in levels of carbonyl protein and reduced glutathione, whereas the levels of nitric oxide and adenosine activity increased significantly only in group IA. Moreover, most of the antioxidant enzymes showed decrease in activity in groups IA and IB.

CONCLUSION:

The data suggest that treatment with carvedilol was effective in attenuating oxidative damage, an effect that may be particularly important in patients with chronic Chagas' disease cardiomyopathy.

• Authors: Patrícia Budni, Roberto Coury Pedrosa, Thais Regina Garlet, Eduardo Monguilhott Dalmarco, Juliana Bastos Dalmarco, Manuel Rosa de Oliveira Lino, Edésio Luiz Simionato, Jorge Antônio Amara, Tânia Sílvia Frode, Danilo Wilhelm Filho
• Journal: Arquivos brasileiros de cardiologia (Arq Bras Cardiol) Vol. 98 Issue 3 Pg. 218-24 (Mar 2012) ISSN: 1678-4170 [Electronic] Brazil
• PMID: 22344676 (Publication Type: Journal Article)

Chemical References

• Adrenergic beta-Antagonists
• Antioxidants
• Biomarkers
• Carbazoles
• Propanolamines
• Carvedilol
• Nitric Oxide
• Adenosine Deaminase
• Glutathione

Topics

• Adenosine Deaminase (metabolism)
• Adrenergic beta-Antagonists (pharmacology)
• Adult
• Aged
• Analysis of Variance
• Antioxidants (pharmacology)
• Biomarkers (metabolism)
• Carbazoles (pharmacology)
• Carvedilol
• Chagas Cardiomyopathy (drug therapy, metabolism)
• Female
• Glutathione (metabolism)
• Humans
• Male
• Middle Aged
• Nitric Oxide (metabolism)
• Oxidative Stress (drug effects)
• Propanolamines (pharmacology)
• Prospective Studies
• Protein Carbonylation (drug effects)