Abstract | BACKGROUND: METHODS: RESULTS:
Celiac disease was identified in 152 patients, and 22 patients had concomitant hypothyroidism (14.5%). Seven cases met inclusion criteria. Overall, 200 control patients were identified. The mean celiac disease pretreatment levothyroxine dose and weight-based levothyroxine dose needed to maintain a euthyroid state were higher in cases than in controls (154 μg vs 106 μg, P=.007, and 2.6 μg/kg vs 1.3 μg/kg, P <.001). Doses decreased significantly after treatment of celiac disease (154 μg vs 111 μg, P=.03; and 2.64 μg/kg vs 1.89 μg/kg, P=.04). All cases required at least 125 μg of levothyroxine initially to maintain a euthyroid state. CONCLUSIONS:
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Authors | Dan Collins, Rebecca Wilcox, Muriel Nathan, Richard Zubarik |
Journal | The American journal of medicine
(Am J Med)
Vol. 125
Issue 3
Pg. 278-82
(Mar 2012)
ISSN: 1555-7162 [Electronic] United States |
PMID | 22340926
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Case-Control Studies
- Celiac Disease
(metabolism)
- Chi-Square Distribution
- Comorbidity
- Female
- Humans
- Hypothyroidism
(drug therapy, metabolism)
- Male
- Middle Aged
- Retrospective Studies
- Thyroxine
(administration & dosage, pharmacokinetics)
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