Abstract | BACKGROUND: METHODS: Female Sprague-Dawley rats were induced to form cystitis by cyclophosphamide (200 mg/kg, ip). The day after the injection, two catheters were inserted into each rat's bladder to study its urodynamics. The BL-410 model bio-function experimental system was used to monitor bladder pressure while the rats were conscious. Unstable detrusor contractions appear in the urine storage period as a standard to determine OAB, and the positive rate was calculated. Urodynamic parameters such as bladder basal pressure (BP), maximum voiding pressure (MVP), intercontraction interval (ICI), spontaneous activity (SA), maximum cystometric capacity (MCC), and bladder compliance (BC) were recorded in each group, and a light microscope was used to observe the pathological changes in the rat bladder tissue. RESULTS: The detrusor instability rate of the model group was 83.33%. The MVP, MCC and BC of rats in the model group were lower than the control group (P < 0.01), and the BP, ICI and SA of the model group rats were higher than the control group (P < 0.01). The difference between the control group and the model group is statistically significant. The model group rats' bladder walls swelled and bled, the submucosa thickened and leukocyte infiltration became serious. CONCLUSIONS:
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Authors | Feng Pan, Di Liu, Xiao-Min Han, Wen-Cheng Li, Zi-Li Pang, Bing Li, Xiao-Ping Zhang, Ya-Jun Xiao, Fu-Qing Zeng |
Journal | Chinese medical journal
(Chin Med J (Engl))
Vol. 125
Issue 2
Pg. 321-5
(Jan 2012)
ISSN: 2542-5641 [Electronic] China |
PMID | 22340567
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Consciousness
- Cyclophosphamide
(toxicity)
- Female
- Rats
- Rats, Sprague-Dawley
- Urinary Bladder, Overactive
(chemically induced, physiopathology)
- Urodynamics
(physiology)
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