Study of validity of pyridinoline and correlation of pyridinoline and beta crosslap in postmenopausal women.

Abstract

This research studied the validity and correlation of beta-CTx (Betacrosslap) and Pyridinoline (PYD) in 71 cases of postmenopausal Thai women who attended at the osteoporosis clinic. The validity consisted of sensitivity, specificity and accuracy of PYD. They were 53.44, 84.6 and 59.15% respectively. So, the validity of pyridinoline test was rather poor and the correlation between betacrosslap and pyridinoline was weak (r = 0.123, p = 0.0001) which was not significant in practice. In conclusion, the pyridinoline test was not proper for bone resorption even pyridinoline was abundant in bone.

• Authors: Narong Bunyaratavej, Shutipen Buranasinsup
• Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet (J Med Assoc Thai) Vol. 94 Suppl 5 Pg. S76-8 (Oct 2011) ISSN: 0125-2208 [Print] Thailand
• PMID: 22338932 (Publication Type: Journal Article)

Chemical References

• Amino Acids
• Biomarkers
• Peptide Fragments
• glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine
• pyridinoline
• Collagen

Topics

• Amino Acids (blood)
• Biomarkers (blood)
• Bone Remodeling (physiology)
• Collagen (blood)
• Female
• Humans
• Middle Aged
• Osteoporosis, Postmenopausal (blood)
• Peptide Fragments (blood)
• Reference Values
• Reproducibility of Results