Serum amyloid P component accelerates the formation and enhances the stability of amyloid fibrils in a physiologically significant under-saturated solution of amyloid-β42.

The mechanism whereby an under-saturated solution of amyloid-β (Aβ)42 precipitates as β sheets in vivo in Alzheimer's disease remains to be elucidated. Herein we present in vitro evidence that serum amyloid P component may mediate this process through its acceleration of amyloid formation from an under-saturated solution of Aβ42 and subsequently its stabilization of the amyloid fibrils formed over physiologically significant timeframes. Our observations support serum amyloid P component as a therapeutic target in Alzheimer's disease.
AuthorsMatthew Mold, Annette K Shrive, Christopher Exley
JournalJournal of Alzheimer's disease : JAD (J Alzheimers Dis) Vol. 29 Issue 4 Pg. 875-81 ( 2012) ISSN: 1875-8908 [Electronic] Netherlands
PMID22337829 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amyloid
  • Amyloid beta-Peptides
  • Krebs-Henseleit solution
  • Peptide Fragments
  • Serum Amyloid P-Component
  • amyloid beta-protein (1-42)
  • Tromethamine
  • Copper
  • Aluminum
  • Magnesium
  • Glucose
  • Calcium
  • Aluminum (pharmacology)
  • Amyloid (drug effects, metabolism, ultrastructure)
  • Amyloid beta-Peptides (pharmacology)
  • Animals
  • Calcium (metabolism)
  • Copper (pharmacology)
  • Dose-Response Relationship, Drug
  • Glucose (pharmacology)
  • Humans
  • Magnesium (pharmacology)
  • Peptide Fragments (pharmacology)
  • Protein Structure, Secondary
  • Serum Amyloid P-Component (drug effects, metabolism, pharmacology, ultrastructure)
  • Time Factors
  • Tomography, X-Ray Computed
  • Tromethamine (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: