Abstract | BACKGROUND: METHODS: We performed a prospective, randomized, open-label, blinded endpoint trial. One hundred six patients who suffered supratentorial ischemic stroke within the previous 1-6 months and subsequently complained of persistent dizziness without other obvious sequelae were enrolled. Patients were randomly given cilostazol (200mg/day) or aspirin (100mg/day) for 6 months. Rates of improvement in the dizziness were then evaluated. Changes in fixation suppression of the vestibulo-ocular reflex (an indicator of cerebral control over the brainstem reflex related to balance), regional cerebral blood flow (CBF) in the cerebrum, cerebellum, and brainstem; and the Zung Self-Rating Depression Scale (SDS) were also evaluated. RESULTS:
Dizziness was significantly improved in the cilostazol group versus the aspirin group (P<0.0001) after the 6-month therapy. The capacity for fixation suppression of the vestibulo-ocular reflex was improved (P<0.0001), and regional CBF in the cerebrum (relative to that in the brainstem [P=0.003] and to that in the cerebello-brainstem [P=0.012]) was increased only in the cilostazol group. There was no statistical difference in the change in SDS scores between the two groups. CONCLUSION:
Cilostazol improves the chronic dizziness that follows ischemic stroke and increases supratentorial CBF and cerebral function for adaptation of the brainstem reflex related to the sense of balance.
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Authors | Ken Johkura, Tamaki N Yoshida, Yosuke Kudo, Yoshiharu Nakae, Takayuki Momoo, Yoshiyuki Kuroiwa |
Journal | Clinical neurology and neurosurgery
(Clin Neurol Neurosurg)
Vol. 114
Issue 7
Pg. 876-80
(Sep 2012)
ISSN: 1872-6968 [Electronic] Netherlands |
PMID | 22336473
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2012 Elsevier B.V. All rights reserved. |
Chemical References |
- Platelet Aggregation Inhibitors
- Tetrazoles
- Cilostazol
- Aspirin
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Topics |
- Aged
- Aged, 80 and over
- Aspirin
(therapeutic use)
- Brain Ischemia
(complications, diagnostic imaging)
- Brain Stem
(blood supply)
- Cerebellum
(blood supply)
- Cerebrovascular Circulation
- Cilostazol
- Depression
(epidemiology, etiology)
- Dizziness
(diagnostic imaging, drug therapy, etiology)
- Endpoint Determination
- Female
- Fixation, Ocular
- Humans
- Male
- Photic Stimulation
- Platelet Aggregation Inhibitors
(therapeutic use)
- Prospective Studies
- Reflex, Vestibulo-Ocular
- Stroke
(complications, diagnostic imaging)
- Tetrazoles
(therapeutic use)
- Tomography, Emission-Computed, Single-Photon
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