[A comparative study of the efficacy of praziquantel and its liposomal form in experimental opisthorchiasis].

Abstract

Intensive and extensive efficacy of praziquantel pure and that included in multilamellar liposomes was studied. As a result, a high anti-helminthic activity of liposomal praziquantel has been established. Negative effect of praziquantel on protein synthetic and enzymatic function of the liver has been revealed in normal animals. The treatment with liposomal praziquantel led to a rapid normalization of total lipid and bilirubin levels, thymol turbidity test, transaminase indices and also to a decrease in dystrophic liver changes.

• Authors: A N Strazhenskikh, O A Molokova, M K Chabanov, V G Bychkov, L S Iarotskiĭ
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 1990 Jul-Aug Issue 4 Pg. 39-41 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'noe izuchenie éffektivnosti prazikvantelia i ego liposomal'noĭ formy pri éksperimental'nom opistorkhoze.
• PMID: 2233537 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Drug Carriers
• Liposomes
• Praziquantel

Topics

• Animals
• Cricetinae
• Drug Carriers
• Drug Evaluation, Preclinical
• Liposomes
• Liver (drug effects, physiopathology)
• Mesocricetus
• Opisthorchiasis (drug therapy, physiopathology)
• Praziquantel (administration & dosage, therapeutic use)