Polymorphism 1558 C > T in the aromatase gene (CYP19A1) in low-grade endometrial stromal sarcoma.

Abstract

Low-grade endometrial stromal sacomas (ESS) are estrogen-sensitive tumors. Polymorphic variation in the CYP19 gene can affect estrogen synthesis by increasing aromatase activity resulting in elevated levels of estrone and estradiol. We examined the polymorphism 1558 C > T in he aromatase gene (CYP19A1) in a series of 20 low-grade endometrial stromal sarcomas. Archival formalinfixed and paraffin-embedded material was analyzed with a fast real-time PCR system. The homozygous C/T- and the homozygous mutant T/T-genotypes were detected in 10/20 (50%) and 7/20 (35%) samples, respectively. Polymorphism 1558 C > T in the aromatase gene may represent a high-risk allele with increased local estrogen levels.

• Authors: O Reich, S Regauer, C Tempfer, C Schneeberger, J Huber
• Journal: European journal of gynaecological oncology (Eur J Gynaecol Oncol) Vol. 32 Issue 6 Pg. 626-7 ( 2011) ISSN: 0392-2936 [Print] Singapore
• PMID: 22335023 (Publication Type: Journal Article)

Chemical References

• Aromatase
• CYP19A1 protein, human

Topics

• Aromatase (genetics)
• Endometrial Neoplasms (genetics, pathology)
• Female
• Genotype
• Humans
• Neoplasm Grading
• Polymorphism, Single Nucleotide
• Sarcoma, Endometrial Stromal (genetics)